Rarely. Most patients who need a breast reduction are not good candidates for liposuction alone, as they tend to have excess skin and their breast and nipples are positioned too low on the chest wall. In those cases, liposuction alone would simply deflate the breast tissue, but the breast would look even droopier, as the skin would not retract. SAFELipo^® is frequently used in combination with a breast reduction to create a better overall shape by reducing the excess fat laterally (on the sides) and under the arms.